裙带菜可溶性膳食纤维对小鼠血管生成素样蛋白3蛋白表达的影响

摘  要 目的：研究裙带菜可溶性膳食纤维对小鼠血管生成素样蛋白3蛋白表达的影响。方法： 40只小鼠分为4组(n=10): 对照组(C57BL/6J小鼠)；高脂模型组(载脂蛋白E缺陷小鼠)，膳食纤维低剂量组(5%)，膳食纤维高剂量组(10%)；经裙带菜可溶性膳食纤维处理8周后，用Western blotting检测血管生成素样蛋白3(Angptl 3)蛋白表达水平。结果： 裙带菜可溶性膳食纤维上调Angptl3蛋白表达水平。结论：裙带菜可溶性膳食纤维能下调小鼠血管生成素样蛋白3蛋白表达。
关键词：裙带菜；可溶性膳食纤维；血管生成素样蛋白3；载脂蛋白E缺陷小鼠

THE EFFECT OF UNDARIA PINNATIFIDA DIETARY FIBER ON THE EXPRESSION OF ANGPTL3 IN MICE
Abstract: Objective：Objective: To study Undaria soluble dietary fiber on mouse angiopoietin-like 3 protein (Angptl 3) expression. Methods: 40 mice were divided into 4 groups (n = 10): control group (C57BL/6J mice); model group (apolipoprotein E-deficient mice), dietary fiber low-dose group (5%) dietary fiber, high-dose group (10%); After treatment for 8 weeks, Angptl 3 protein expression was determined by Western blotting. Results: Undaria pinnatifida soluble dietary fiber decreases the protein expression of Angptl3. Conclusion: Undaria pinnatifida soluble dietary fiber can lower the protein expression of Angptl 3 in mice.
Key words: Undaria pinnatifida; Soluble dietary fiber; angiopoietin-like protein 3; apolipoprotein E deficient mice

目    录        4100字
摘  要    1
关键词    1
1  前言    2
2  材 料 与 方 法    2
2.1  待检样本及试剂    2
2.2  实验动物及分组    2
2.3  Angptl 3蛋白表达的Western blotting分析    2
2.4  统计分析    3
3   结  果    3
4   讨  论    4
参考文献    5
致    谢    7